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Patients with panic disorder plus agoraphobia had 8 weeks of drug treatment ( alprazolam or placebo)plus psychological treatment (exposure or relaxation).
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Ex-alprazolam and ex-exposure patients did not differ significantly on any variable at the 3.5-year follow-up. No baseline variable predicted outcome at follow-up
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Benzodiazepines, particularly alprazolam, have been shown to be effective in the treatment of panic disorder. However, difficult withdrawal and high relapse
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