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Depending on the quantity, type, frequency, and duration of opioid use, the physical withdrawal symptoms last for as little as forty-eight to seventy-two hours ( for

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Gowing L, Farrell M, Ali R, et al. Alpha2 adrenergic agonists for the management of opioid withdrawal. and 3 RCTs compared lofexidine with clonidine. Inten-


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