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Actually, Effexor and Pristiq are related but Pristiq is a structurally novel compound. Maybe your MD can add Wellbutrin XL that has worked very well for me . still have good and bad days but nothing compared to Effexor.
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On the positive side, Effexor is an amazing antidepressant, I tried wellbutrin first and it didn't help compared to the Effexor. Everyone is different
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